Nicardipine hydrochloride injection is used for hypertensive emergencies and acute heart failure. The United States Pharmacopeia and the National Formulary (USP-NF 2022 ISSUE 2 *) uses a silica-based amino column to measure the sorbitol content in nicardipine hydrochloride injection. In this application, Asahiak NH2P-50 4E, a polymer-based amino column, was used to analyze sorbitol using the USP monograph as a reference. The result confirmed the feasibility of NH2P-50 4E for the sorbitol analysis.
*The version at the time of the application acquisition.
Sample: 25 µL
- 1.Sorbitol 4.8 mg/mL
- ：Shodex Asahipak NH2P-50 4E (4.6 mm I.D. x 250 mm)
- ：CH3CN and 1 g/L of Tetrabutylammonium hydrogen sulfate in water (70:30)
- Flow rate
- ：1.0 mL/min
- ：RI (50 ℃)
- Column temp.
- ：40 ℃
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