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Analysis of Ibandronate Sodium (I-524A)


Bisphosphonates are the medicines used to treat osteoporosis by preventing bone absorption. In this application, the second generation ibandronate sodium was analyzed using a non-suppressor type anion chromatography column, IC I-524A.

Sample: 100 µL
1. Ibandronate sodium 2 mg/mL
dissolved in H2O

Column       : Shodex IC I-524A (4.6 mm I.D. x 100 mm)
Eluent       : 0.47 mL of Formic acid in 2500 mL of Water, pH3.5
               (adjusted with 2 N NaOH aq.)
Flow rate    : 1.0 mL/min
Detector     :  RI
Column temp. : 35 °C

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