Liraglutide, a drug used for diabetes treatment, was analyzed using PROTEIN KW-802.5, an aqueous-based SEC (GFC) column. After heat treatment of the formulation, it can be noted that the peak areas that are considered as oligomers are more significant. The resolution between the monomer and oligomer 1 of liraglutide achieved was 2.4 and it was confirmed that the column is suitable for the separation of high molecular weight impurities for liraglutide formulations.
- (Note)
- Upon the completion of analysis, immediately replace the eluent with shipping eluent.
Sample: 5 µL
Liraglutide formulation (5-fold diluted with H2O)
- 1.Liraglutide monomer
- 2.Phenol
- Column
- :Shodex PROTEIN KW-802.5 (8.0 mm I.D. x 300 mm)
- Eluent
- :1 mg/mL L-Arginine aq./CH3CN/CH3COOH=35/50/15
- Flow rate
- :0.5 mL/min
- Detector
- :UV (280 nm)
- Column temp.
- :30 ℃
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Product Name Index
Applications
- Basic Drugs : Under Neutral Condition
- Basic Drugs : Effects of Eluent pH
- Basic Drugs : Effects of Ion Concentration
- Effects of pH of Eluent on Elution Volume and Plate Number (ODP-50 4D)
- Antifebriles (1) (DS-613)
- Antifebriles (2) (DM-614)
- Antipyretic Analgesics (ODP-50 4D)
- Diuretics (1) (ODP-50 4D)
- Diuretics (2) (DE-613)
- Anti Cancer Drugs (ODP-50 4D)
- Drugs (ODP-50 4D)
- Anti Inflammatory Drugs (1) (ODP-50 4E)
- Anti Inflammatory Drugs (2) (ODP-50 4E)
- Scopolamine and Atropine
- Tetracaine (ODP-50 4D)
- Procainamides (1) (DE-613)
- Procainamides (2) (DE-413)
- Procaine and Procaineamide (ODP-50 4D)
- Methylxantines (1) (DS-613)
- Methylxantines (2)
- Local Anesthetics (1) (ODP-50 4D)
- Local Anesthetics (2) (DE-413)
- Cinchona Alkaloids
- Antibiotics (1) (ODP-50 4D)
- Antibiotics (2) (DE-413)
- Sulfanilamides (DE-413)
- Barbiturates (ODP-50 4D)
- Effects of pH of Eluent on Sensitivity of Barbital
- Berberine in Japanese Goldthread (ODP-50 4D)
- Glycyrrhizin in Licorice (ODP-50 6D)
- Saikosaponins (ODP-50 6D)
- Soyasaponin in Soy Bean (DS-613)
- Curative Drugs to Eradicate H.Pyrori (JJ-50 2D)
- Enalapril Maleate (DS-413)
- Tetracycline Derivative Antibiotics (ODP-40 4D)
- Short Amines (ODP2 HP)
- Ginsenoside (Ginseng Saponin) (DS-413)
- Ginsenoside (Carrot Saponin) (NH2P-50 4E)
- Analysis of Macrolide Antibiotics and Derivatives (ODP-50 4D)
- Ribavirin (KS-801)
- Anti-diabetes Drugs (NH2P-50 4E)
- LC/MS/MS Analysis of Oral Anti-diabetes Drugs (VC-50 2D)
- Characterization of Polymeric Excipients by SEC-IR (SB-806M HQ)
- Simultaneous Analysis of Multi Symptom Cold Formula (ODP2 HP)
- LC/MS Analysis of Statins (ODP2 HP-2B)
- LC/MS Analysis of Metformin (NH2P-40 2D)
- Separation of Gingerol and Shogaol (C18M 4D)
- Bibliographic Information for Analysis of Conjugate Vaccine
- LC/MS/MS Analysis of Organic Sulfonic Acids (VT-50 2D)
- Analysis of Allantoin in a Commercial Disinfectant (VG-50 4E)
- LC/MS Analysis of Aminoglycoside Antibiotics (VC-50 2D)
- LC/MS/MS Analysis of Ribavirin (VC-50 2D)
- LC/MS/MS Analysis of Salacia Extract (1) (VC-50 2D)
- LC/MS/MS Analysis of Salacia Extract (2) (VT-50 2D)
- Comparison of Analysis of Glucosamine Hydrochloride between Polymer-based Amino Columns and Silica-based Amino Columns
- LC/MS Analysis of Streptomycins (VC-50 2D)
- LC/MS/MS Analysis of Citicoline (VT-50 2D)
- SEC Analysis of Antibody Drug Conjugate (LW-803)
- SEC Analysis of Saccharated Ferric Oxide Injection (SB-804 HQ + SB-802.5 HQ)
- Analysis of α-GPC in Supplements (NH2P-50 4E)
- SEC Analysis of Rituximab (LW-803)
- Analysis of Trypsin-Digested Rituximab (C18U 2D)
- PEG-Chymotrypsin (KW-802.5)
- SEC Analysis of PEG-Asparaginase (SB-806 HQ)
- LC/MS Analysis of Macrolide Antibiotics (C18U 2B)
- SEC Analysis of Filgrastim (KW-803)
- Analysis of Levocarnitine (NH2P-50 4E)
- Analysis of Inositol According to Japanese Pharmaceutical Excipients 2018 (KS-801)
- Analysis of Sodium Risedronate (IC I-524A)
- Analysis of Ibandronate Sodium (I-524A)
- Analysis of Zoledronic Acid (IC I-524A)
- Separation of Fosfomycin and its Thermal Decomposition Products (NH2P-50 4E)
- Analysis of Semaglutide Formulation (KW-802.5)
- Analysis of Ferric Carboxymaltose (SB-804 HQ + SB-802.5 HQ)
- Quantitative Analysis of Sucrose in Saccharated Iron Oxide Injection (VG-50 4E)
- Analysis of Carboplatin (NH2P-50 4E)
- Separation of Ceftazidime and Arginine (KW402.5-4F)
- Analysis of Sorbitol in Nicardipine Hydrochloride Injection (NH2P-50 4E)
- SEC Analysis of Etelcalcetide Hydrochloride (KW-802.5)