Antibody Drug Conjugates (ADCs) are a class of drugs where an antibody is linked to a small-molecule drug via a linker. This combines both the advantages of current small-molecule drugs as well as antibody drugs, and are attracting attention as the next-generation drug.
Here, an antibody drug conjugate formulation was analyzed using the aqueous SEC (GFC) column, PROTEIN LW-803. Besides monomers, a peak that appeared to be dimers was confirmed. The LW-803 is applicable for complex ADCs impurity analysis.
Sample : 20 µL
formulation 5 mg/mL
Column : Shodex PROTEIN LW-803 (8.0 mm I.D. x 300 mm) Eluent : 50 mM Sodium phosphate buffer (pH7.0) + 0.3 M NaCl/CH3CN=90/10 Flow rate : 1.0 mL/min Detector : UV (280 nm) Column temp. : 25 °C
Sample Name Index
Operation Manual / Certificate of Analysis
Operation Manuals and Certificate of Analysis / Inspection Certificate for the following products can be downloaded here.