According to the United States Pharmacopeia and the National Formulary (USP43-NF38*), the European Pharmacopoeia (EP 10.4*), and the Japanese Pharmacopoeia (JP XVII*), analysis of formic acid for "Povidone", should be carried out with a column filled with strong acidic ion-exchange resin (USP-NF L17). The RSpak KC-811, a column filled with L17 packing material, confirmed the requirements were met. Using the same condition, we analyzed povidone K-30. The elution of formic acid was observed by comparing the elution position of the formic acid standard.

Theoretical plate number: ≥ 1,000
Symmetry factor: 0.5 - 1.5
Relative standard deviation (RSD): ≤ 2.0% (repeated 6 times)

*The version at the time of the application acquisition.

Sample: 50 µL
(Povidone K-30) 20 mg/mL in H₂O
(Standard solution) 0.01 mg/mL of Formic acid in H₂O

1. 1.Formic acid