Solvent Replacement Applicability of Organic SEC (GPC) Columns

Please refer to the following tables for the classification of solvents in terms of capability of being replaced with original in-column solvent. However, frequent replacement of in-column solvent may shorten column life, and is, therefore, not recommended.

Refer to Solvent Exchange Procedures for Shodex GPC Series Columns

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Solvent Product Name
Shipping Solvent: THF
KF-801

KF-802

KF-802.5

KF-803L

KF-804L

 KF-803

KF-804

KF-805

KF-805L

KF-806M

KF-806L

KF-807L

KF-401HQ

KF-402HQ

KF-402.5HQ

 KF-403HQ

LF-804

LF-604

LF-404

Tetrahydrofuran (THF)

 ✓ ✓ ✓ ✓ ✓ ✓ ✓
Chloroform ✓ ✓ ✓ ✓ ✓ ✓ ✓
Carbon tetrachloride ✕ ✓ ✓ ✓     ✓
Benzene ✓ ✓ ✓ ✓ ✓ ✓  
Toluene ✓ ✓ ✓ ✓ ✓ ✓ ✓
p-Xylene ✕ ✓ ✓ ✓ ✓ ✓  

o-Dichlorobenzene (ODCB)

 ✕ ✕ ✓ ✓ ✓ ✓  

1,2,4-Trichlorobenzene (TCB)

 ✕ ✕ ✓ ✓ ✓ ✓  
Dioxane ✕ ✓ ✓ ✓      
Diethyl ether ✕ ✕ ✓ ✓      
Ethyl acetate ✕ ✕ ✓ ✓      
Acetone ✕ ✕ ✓ ✓ ✓ ✓ ✓

Methyl ethyl ketone (MEK)

 ✕ ✕ ✓ ✓ ✓ ✓ ✓

N,N-Dimethylformamide (DMF)

 ✕ ✕ ✓ ✓ ✓* ✓* ✓*

N,N-Dimethylacetmide (DMAc)

 ✕ ✕ ✓ ✓ ✓* ✓* ✓*

Hexafluoroisopropanol (HFIP)

 ✕ ✕ ✕ ✓ ✕ △* ✓*
m-Cresol ✕ ✕ ✓ ✓      
o-Chlorophenol ✕ ✕ ✓ ✓      
Quinoline ✕ ✕ ✓ ✓      

N-Methyl-2-pyrrolidone (NMP)

 ✕ ✕ ✓ ✓ ✓* ✓* ✓*

Dimethyl sulfoxide (DMSO)

 ✕ ✕ ✕ ✕ △* ✓* ✓*

30 % m-Cresol/Chloroform

 ✕ ✓ ✓ ✓     ✓

30 % m-Chlorophenol/Chloroform

 ✕ ✓ ✓ ✓     ✓

30 % HFIP/Chloroform

 ✕ ✓ ✓ ✓      
Hexane ✕ ✕ ✕ ✕ ✕ ✕ ✕
Acetonitrile ✕ ✕ ✕ ✕ ✕ ✕ ✕
Methanol ✕ ✕ ✕ ✕ ✕ ✕ ✕
Water ✕ ✕ ✕ ✕ ✕ ✕ ✕
✓
: Solvent replacement possible
△
:
 Solvent replacement possible, but this may cause column performance to deteriorate slightly
*
  : Usable at 40 °C or higher
✕
: Solvent replacement not possible
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Solvent Product Name
Shipping Solvent: DMF

KD-801

KD-802

KD-802.5

 KD-803

KD-804

KD-805

KD-806

KD-806M

KD-807
Tetrahydrofuran (THF) ✕ ✕ ✓
Chloroform ✕ ✕ ✓
Carbon tetrachloride ✕ ✕ ✓
Benzene ✕ ✓ ✓
Toluene ✕ ✓ ✓
p-Xylene ✕ ✓ ✓
o-Dichlorobenzene (ODCB) ✕ ✓ ✓
1,2,4-Trichlorobenzene (TCB) ✕ ✓ ✓
Dioxane ✕ ✓ ✓
Diethyl ether ✕ ✓ ✓
Ethyl acetate ✕ ✕ ✓
Acetone ✕ ✓ ✓
Methyl ethyl ketone (MEK) ✕ ✓ ✓
N,N-Dimethylformamide (DMF) ◯ ✓ ✓
N,N-Dimethylacetmide (DMAc) ✕ ✓ ✓
Hexafluoroisopropanol (HFIP) ✕ ✓ ✓
m-Cresol ✕ ✓ ✓
o-Chlorophenol ✕ ✓ ✓
Quinoline ✕ ✓ ✓
N-Methyl-2-pyrrolidone (NMP) ✕ ✓ ✓
Dimethyl sulfoxide (DMSO) ✕ ✕ ✓
30 % m-Cresol/Chloroform ✕ ✓ ✓
30 % m-Chlorophenol/Chloroform ✕ ✓ ✓
30 % HFIP/Chloroform ✕ ✓ ✓
Hexane ✕ ✕ ✕
Acetonitrile ✕ ✕ ✕
Methanol ✕ ✕ ✕
Water ✕ ✕ ✕
✓
:Solvent replacement possible
✕
: 
Solvent replacement not possible

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