Monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA; also known as cacodylic acid) are metabolites of inorganic arsenic compounds and are used as herbicides. In this application, IC SI-35 2B, a column for anion analysis, was used with an LC/MS to analyze MMA and DMA. SI-35 2B was feasible separating and eluting MMA and DMA within 2 minutes. Meanwhile, arsenobetaine, an organic arsenic compound commonly found in marine products, is weakly retained under the condition used and elutes before MMA and DMA. Therefore, presence of arsenobetaine does not affect the analysis of MMA and DMA.
Sample: 50 ng/mL each, 1 µL
- Arsenobetaine
- MMA; Monomethylarsonic acid
- DMA; Dimethyl arsinic acid
- Column
- :Shodex IC SI-35 2B (2.0 mm I.D. × 50 mm)
- Eluent
- :20 mmol/L NH4HCO3 aq.
- Flow rate
- :0.2 mL/min
- Detector
- :ESI-MS (positive, SIM)
- Column temp.
- :40 ℃
Sample Name Index
Operation Manual / Certificate of Analysis
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Applications
- Analysis of Haloacetic Acids (JJ-50 2D)
- LC/MS Analysis of Haloacetic Acids (JJ-50 2D)
- Melamine (1) (NH2P-50 4E)
- Melamine (2) (NH2P-50 2D)
- LC/MS Analysis of Melamine and Cyanuric Acid (NH2P-40 2D)
- Melamine and Related Substances (VG-50 4D)
- Effects of Eluent Composition Ratios on PFOS and PFOA Analysis (JJ-50 2D)
- Analysis of PFAS (VT-50 2D)
- Analysis of PFAS According to Japanese Industrial Standards Method (JJ-50 2D)