Diethylene glycol (DEG) and ethylene glycol (EG) may become contaminates through improper manufacturing processes of raw materials or through contaminated solvents and excipients used in certain product productions. In April 2023, the U.S. Food and Drug Administration (FDA) issued a guidance for industries regarding testing for DEG and EG in pharmaceutical ingredients that have high potentials of DEG and EG contamination. OHpak SB-802 HQ, a column for aqueous SEC (GFC), used in this application is feasible separating DEG, EG, propylene glycol, and a sugar alcohol, sorbitol.
Sample: 50 µL
0.01 mg/mL each
- 1.Sorbitol
- 2.Diethylene glycol
- 3.Ethylene glycol
- 4.Propylene glycol
- Column
- ：Shodex OHpak SB-802 HQ (8.0 mm I.D. x 300 mm)
- Eluent
- ：H2O
- Flow rate
- ：0.5 mL/min
- Detector
- ：RI
- Column temp.
- ：30 ℃
Sample Name Index
Operation Manual / Certificate of Analysis
Operation Manuals and Certificate of Analysis / Inspection Certificate for the following products can be downloaded here.
Product Name Index
Applications
- Aliphatic Alcohols (1) (SH1011, SH1821)
- Aliphatic Alcohols (2) (DE-613)
- Aliphatic Alcohols (3) (ODP-50 6D)
- Aliphatic Alcohols (4) (KC-811)
- Aliphatic Alcohols (5) (SC1211)
- Aliphatic Alcohols (6) (SH1011)
- Diols (DE-613)
- Analysis of Glycols (SP0810)
- Analysis of Ethylene Glycol and Diethylene Glycol in reference to USP-NF “Polyethylene Glycol 3350” (SB-802 HQ)
- Aromatic Alcohols (DE-613)
- Effects of Acetonitrile Concentration in Analysis of Alcohols (SC1211)
- Glycerin and Glyceric Acid Analysis (SH1011)
- Amino Alcohols (1) (KD-802 + KD-801)
- Analysis of Amino Alcohols (YK-421)
- Ketones (DS-413)
- Ketones (2) (DE-413)