Methacrylic Acid Copolymer (KF-806M)

Eudragit L100 (methacrylic acid copolymer L) is used as an additive (coating agent) in pharmaceuticals and it was analyzed with GPC KF-806M, a column used for organic solvent type SEC (GPC). A mixture of THF and acetone was used as the eluent. PMMA (polymethyl methacrylate) is suitable as a calibration standard for calculating molecular weight distribution because a good calibration curve can be obtained with the THF/acetone eluent.


Sample : 20 μL
Methacrylic acid copolymer L
(EUDRAGIT® L 100) 0.4 % (v/v)


Column       : Shodex GPC KF-806M (8.0 mm I.D. x 300 mm)
Eluent       : THF/Acetone=50/50
Flow rate    : 1.0 mL/min
Detector     : RI
Column temp. : 40 °C

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