LC/MS analysis of drugs in BSA was performed using polymer-based column ODP2 HP. Each drug has peak areas between 83 -100 % (peak areas without BSA are set as 100 %), which means a good separation without receiving ion suppression from protein.
Sample : drugs 500ng/mL each in BSA (7.0 mg/L), 5 μL
Lidocaine
Chlorpheniramine
Propranolol
Diphenhydramine
Bupivacaine
Verapamil
Imipramine
Sample : drugs 500ng/mL each in BSA (7.0 mg/L), 5 μL
Lidocaine
Chlorpheniramine
Propranolol
Diphenhydramine
Bupivacaine
Verapamil
Imipramine
Column : Shodex ODP2 HP-2B (2.0 mm I.D. x 50 mm) Eluent : 10 mM Ammonium acetate aq./CH3CN=70/30 Flow rate : 0.2 mL/min Detector : UV (280 nm), ESI-MS (SIM Positive) Column temp. : 40 °C
Sample Name Index
Operation Manual / Certificate of Analysis
Operation Manuals and Certificate of Analysis / Inspection Certificate for the following products can be downloaded here.
Product Name Index
Applications
- Indomethacin in Serum (ODP-50 6E)
- Procainamide in Serum (ODP-50 4D)
- LC/MS Analysis of Barbital in BSA (ODP2 HP-2B)
- LC/MS Analysis of Drugs in BSA (2) (ODP2 HP)
- LC/MS/MS Analysis of Tricyclic Antidepressants in BSA (ODP2 HP)
- LC/MS Analysis of Drugs in Control Serum (ODP2 HP)
- Reproducibility in LC/MS Analysis (ODP2 HP)
- Influence of Proteins in LC/MS Analysis (ODP2 HP-2B)
- Direct Analysis of Acetaminophen in Serum (ODP2 HP)
- Direct Analysis of Risperidone in Urine (ODP2 HP)
- Simultaneous Analysis of Multi Symptom Cold Formula in Serum (ODP2 HP)
- Analysis of Anticonvulsant in Serum (ODP2 HP)
- Hippuric Acid etc. in Urine (2)