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Hydroxypropyl-β-cyclodextrin (SB-802.5 HQ)


Hydroxypropyl-β-cyclodextrin is added to pharmaceuticals, including vaccines, to improve the solubility in water, stabilizing, etc. It is also expected to be used as *adjuvant in recent years. In this application, trypsin inhibitor and hydroxypropyl-β-cyclodextrin were separated using OHpak SB-802.5 HQ​. It is possible to measure and quantify hydroxypropyl-β-cyclodextrin without deproteinization by using a column for SEC. The calibration curve shows good linearity in the range from 0.05 to 10mg/mL.
*Adjuvant: Generic term for factors that enhance the effect of vaccines

Sample : 1mg/mL each, 50µL
1. Trypsin Inhibitor
(MW: 20,000)
2. Hydroxypropyl-β-cyclodextrin

Columns      : Shodex OHpak SB-802.5 HQ (8.0mmI.D. x 300mm) x 2
Eluent       : **PBS(-)/CH3CN=80/20
Flow rate    : 1.0mL/min
Detector     : Shodex RI
Column temp. : 30°C

**PBS(-) Phosphate buffered saline without calcium and magnesium

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